Transfer RNA biogenesis: A visa to leave the nucleus
نویسندگان
چکیده
Only correctly folded and mature tRNAs can leave the nucleus and enter the cytoplasm. Surprisingly, tRNA-aminoacylation has been found to occur, not only in the cytosol, but also inside the nucleus, where it may act as an additional proofreading step and facilitate the export of 'ready-to-function' aminoacyl-tRNAs.
منابع مشابه
Characterization of RNAs that do and do not migrate between cytoplasm and nucleus.
We have investigated the nature of the RNA that moves from cytoplasm to nucleus against a concentration gradient in Amoeba proteus. We find that: In the presence of actinomycin D an unlabeled nucleus grafted into a [(3)H]RNA cytoplasm acquires RNAs with sedimentation constants 30 S, 19 S, and 4-6S that are not related to the general population of cytoplasmic ribosomal and transfer RNAs. RNAs of...
متن کاملاثر ویژگی های رسوب بر تجمع و نرخ انتقال فلزات سنگین در درختان مانگرو (مطالعه موردی: خلیج نایبند و جزیره قشم)
In this paper, the accumulation of heavy metals of Nickel (Ni) and Vanadium (V) was measured in habitat sediments, mangrove roots and leaves (Avicennia marina). Besides, the transfer of Ni and V from the sediment to root and to the leaves in Nayband Bay and Qeshm Island were studied. The samples were gathered by Systematic-random Sampling using selective transects at 16 stations at the end of m...
متن کاملPlant snRNP Biogenesis: A Perspective from the Nucleolus and Cajal Bodies
Small nuclear ribonucleoproteins (snRNPs) are protein-RNA complexes composed of specific snRNP-associated proteins along with small nuclear RNAs (snRNAs), which are non-coding RNA molecules abundant in the nucleus. snRNPs mainly function as core components of the spliceosome, the molecular machinery for pre-mRNA splicing. Thus, snRNP biogenesis is a critical issue for plants, essential for the ...
متن کاملTLC1 RNA nucleo-cytoplasmic trafficking links telomerase biogenesis to its recruitment to telomeres.
The yeast telomerase holoenzyme, which adds telomeric repeats at the chromosome ends, is composed of the TLC1 RNA and the associated proteins Est1, Est2 and Est3. To study the biogenesis of telomerase in endogenous conditions, we performed fluorescent in situ hybridization on the native TLC1 RNA. We found that the telomerase RNA colocalizes with telomeres in G1- to S-phase cells. Strains lackin...
متن کاملiRhom2 is essential for innate immunity to RNA virus by antagonizing ER- and mitochondria-associated degradation of VISA
VISA (also known as MAVS, IPS-1 and Cardif) is an essential adaptor protein in innate immune response to RNA virus. The protein level of VISA is delicately regulated before and after viral infection to ensure the optimal activation and timely termination of innate antiviral response. It has been reported that several E3 ubiquitin ligases can mediate the degradation of VISA, but how the stabilit...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید
ثبت ناماگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید
ورودعنوان ژورنال:
- Current Biology
دوره 9 شماره
صفحات -
تاریخ انتشار 1999